Single-cell Omics
PDAC Spatial Transcriptomics Analysis
- scRNA-seq
- spatial transcriptomics
- Python
- R
Overview
Analyzed the intersection of nerves and tumor cells in Pancreatic Ductal Adenocarcinoma (PDAC) to understand how the microenvironment facilitates perineural invasion.
Key highlights
- Performed integrative analysis of scRNA-seq and Visium spatial data using the Scanpy ecosystem.
- Applied the RCTD algorithm to deconvolute cell type proportions within specific spatial spots.
- Dissected cell-cell interactions near nerve structures to identify potential drivers of tumor progression.
